There are 2 owner-reported engine complaints for the 2022 Ford E-450in NHTSA's database. These are unverified consumer reports and may not reflect confirmed defects.
We operate numerous 7.3L Ford engine equipped vehicles in our fleet of ambulances. Over the past year we have experienced 4 engine failures of this 7.3L engine in vehicles ranging form around 60,000 to 90,000 after exceeding the service recommendations stated from the manufacturer. I have contacted the Ford Pro Fleet experts and have asked repeatedly about what could be causing the failures, trying to figure out if we are doing something wrong in our maintenance or operation. They assure us we are not doing anything wrong, however we continue to lose engines. Each time the repair bill is around $12,000. We have been lucky that Ford has offered financial assistance, but now that has gone away. At first, we were told that we were the only ones experiencing these failures, but now I am hearing from other operators of similar vehicles that they are experiencing the same concern. We cannot afford to keep replacing engines in relatively new vehicles, especially when there is an apparent defect in parts or standard operation. Symptoms we experience that lead to engine replacement are loss of power while driving caused my multiple cylinder misfires. Loss of power while running an emergency call pose a significant safety risk to operators and patients.
The contact owns a 2022 Ford E-450. The contact stated while driving 60 MPH, the steering wheel felt loose, and the vehicle was difficult to control. The check engine warning light was illuminated. The vehicle was taken to the dealer and the dealer stated no failure was found, but the failure persisted. The vehicle was taken back to the dealer and the vehicle was repaired. The contact was unsure what was repairs were made or what parts were replaced. The failure persisted. The manufacturer was not contacted. The failure mileage was 3,000.
Complaints are unverified consumer reports submitted to NHTSA. A high complaint count may reflect vehicle popularity, not defect severity. Data sourced from NHTSA public records.
Data synced from NHTSA on May 4, 2026