There are 2 owner-reported powertrain & transmission complaints for the 2021 Mercedes-Benz E-Classin NHTSA's database. These are unverified consumer reports and may not reflect confirmed defects.
With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .
The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.
Complaints are unverified consumer reports submitted to NHTSA. A high complaint count may reflect vehicle popularity, not defect severity. Data sourced from NHTSA public records.
Data synced from NHTSA on Apr 26, 2026